Palmitoyl Hexapeptide-12 is a matrikine peptide derived from elastin fragments that signals fibroblasts to produce elastin, fibrillin, and collagen. The palmitoyl fatty acid chain enhances skin penetration and stability. By stimulating the entire dermal matrix (not just collagen), it provides comprehensive anti-aging support. Particularly effective for improving skin elasticity and resilience in sagging skin.
Key Skin Benefits
+ Stimulates elastin and fibrillin — beyond collagen
+ Enhances skin elasticity and resilience
+ Palmitoyl chain for enhanced penetration
+ Comprehensive dermal matrix support
+ Targets sagging and loss of firmness
Pros
+ + Elastin + fibrillin + collagen stimulation
+ + Palmitoylated — good penetration
+ + Targets comprehensive dermal matrix
+ + Addresses skin elasticity beyond collagen
Cons
− − Less known than Matrixyl
− − Expensive peptide
− − Limited independent clinical trials
− − Best in blends
Specifications
Property
Value
Usage Areas
Face, Eye, Body
Product Type
Leave-On
Source
Synthetic
Natural Level
Synthetic
Safety Ratings
Metric
Rating
Skin Sensitivity
1/5
Comedogenic Rating
0/5
EWG Score
1/10
Regional Regulatory Limits
Region
Leave-on %
Rinse-off %
Status
EU (CosIng)
No limit
No limit
Allowed
US (CIR/FDA)
No limit
No limit
Allowed
Japan (MHLW)
No limit
No limit
Allowed
ASEAN
No limit
No limit
Allowed
China (NMPA)
No limit
No limit
Allowed
Typical Usage % by Product Type
Product Type
Typical %
Serum
2 - 5 ppm
Moisturizer
1 - 3 ppm
References
Antonicelli F et al. — Elastin-derived peptides and skin. Exp Gerontol (2007). PMID: 17126509
Debelle L, Tamburro AM — Elastin biochemistry. Int J Biochem Cell Biol (1999). PMID: 10200621
Supplier technical data — palmitoyl hexapeptide-12