Hexapeptide-11 is a synthetic yeast-derived peptide that stimulates collagen XVII (BP180) — a key hemidesmosome protein anchoring epidermis to dermis. By strengthening the dermal-epidermal junction (DEJ), it improves skin firmness, resilience, and reduces sagging. Targets the structural integrity of the skin's basement membrane rather than bulk collagen production. One of the few peptides specifically addressing the DEJ — a critical anti-aging target.
Key Skin Benefits
+ Stimulates collagen XVII — strengthens dermal-epidermal junction
+ Improves skin firmness and resilience
+ Targets sagging at structural level
+ Fermentation-derived peptide — unique origin
+ Works at low concentrations for skin anchoring
Pros
+ + Targets DEJ — unique anti-aging mechanism
+ + Fermentation-derived — natural-like origin
+ + Clinically tested for firmness
+ + Works at ppm concentrations
Cons
− − Less research than mainstream peptides
− − Expensive specialized peptide
− − Results take 4-8 weeks
− − Best in peptide blends
Specifications
Property
Value
Usage Areas
Face, Eye, Body
Product Type
Leave-On
Source
Synthetic
Natural Level
Synthetic
Safety Ratings
Metric
Rating
Skin Sensitivity
1/5
Comedogenic Rating
0/5
EWG Score
1/10
Regional Regulatory Limits
Region
Leave-on %
Rinse-off %
Status
EU (CosIng)
No limit
No limit
Allowed
US (CIR/FDA)
No limit
No limit
Allowed
Japan (MHLW)
No limit
No limit
Allowed
ASEAN
No limit
No limit
Allowed
China (NMPA)
No limit
No limit
Allowed
Typical Usage % by Product Type
Product Type
Typical %
Serum
1 - 10 ppm
Moisturizer
1 - 5 ppm
References
Nishie W et al. — Collagen XVII in skin. Exp Dermatol (2011). PMID: 21488970
Cosmetic peptide references — active ingredient supplier data