Glycine

What Is Glycine?

Glycine is the simplest amino acid and constitutes approximately 33% of collagen's amino acid sequence — every third residue in collagen is glycine. This unique abundance makes it essential for collagen triple-helix formation. Also functions as an NMF component, neurotransmitter, and detoxification agent in skin cells. In skincare, glycine supports collagen structure, provides lightweight hydration, and enhances the penetration of other amino acids.

Key Skin Benefits

• + 33% of collagen amino acid composition — structural essential
• + Every third residue in collagen — triple-helix formation
• + NMF component — skin hydration
• + Supports natural collagen structure
• + Lightest amino acid — excellent penetration

Pros

• + + Most abundant amino acid in collagen
• + + Essential for collagen structure
• + + Natural NMF component
• + + Excellent safety
• + + Very affordable

Cons

• − − Not a stand-alone anti-aging active
• − − Works best in amino acid blends
• − − Minimal research as monotherapy

Specifications

Safety Ratings

Regional Regulatory Limits

Typical Usage % by Product Type

References

1. Shoulders MD, Raines RT — Collagen structure. Annu Rev Biochem (2009). PMID: 19344236
2. Rawlings AV et al. — NMF components. J Invest Dermatol (1994)
3. Brinckmann J et al. — Collagen primer (2005). Springer